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"I think, therefore I am"
好奇心是科學工作者產生無窮的毅力和耐心的源泉--愛因斯坦
林能裕博士/ Neng-Yu Lin PhD
現職:台大醫學院 解剖學暨細胞生物學研究所 助理教授
Position: National Taiwan University College of Medicine
Graduate Institute of Anatomy and Cell Biology, Assistant Prof.
學歷:德國艾朗根-紐倫堡大學 細胞生物學/臨床免疫學 博士 (Dr. rer. nat.)
Degree: PhD of University of Erlangen-Nuremberg, Germany
Department of Medicine 3 for Rheumatology and Clinical Immunology
研究領域:
腫瘤細胞生物學/Cancer biology
骨細胞生物學(關節炎/骨質疏鬆)/Rheumatoid Arthritis, Osteoporosis,Osteoarthritis
組織纖維化/Fibrosis
實驗技術:
老鼠腫瘤模型/Tumor xenograft mouse model; Bone metastasis model
老鼠關節炎模型/CAIA mouse model; K/BxN serum-transfer arthritis (STA) model; Ovariectomy mouse model; DMM model; aging induced osteoarthritis model
老鼠纖維化模型/fibrosis model
我們在做什麼
研究領域/Research area
組織纖維化/Fibrosis
纖維化(Fibrosis)是指在一個器官或組織為修復或反應過程而過度地形成纖維結締組織的過程,這纖維母細胞的修復機制是一個雙面刃,當不及時,會使傷口無法有效癒合。然而過度活化又會不受調控地合成細胞外基質造成組織纖維化,這是許多疾病的發病機制,影響層面廣泛至全身各個器官,例如肺纖維化、肝纖維化。由於這些疾病高死亡率和缺乏有效的治療方法,必須著手探討纖維化疾病的分子病理機制和新的抗纖維化療法。其中,在病理性纖維化的主要中樞調節因子中,β型轉化生長因子(TGFβ)透過不同的訊息途徑來刺激纖維母細胞的分化機制已被反覆地驗證與討論。希望我們透過纖維母細胞的研究,能找出組織進行修復與纖維化的關鍵因素,進行標靶藥物開發出專一性抗纖維化診斷與治療。
骨細胞生物學/Osteobiology
骨骼是組成脊椎動物內骨骼的堅硬器官,功能是運動、支持和保護身體,製造紅血球和白血球,以及儲藏礦物質。但骨骼並非是一個靜態的器官,會隨著成骨細胞(osteoblast)與噬骨細胞(osteoclast)的協調達成動態平衡,過與不及皆會導致疾病,例如類風濕性關節炎以及骨質疏鬆症皆是因為致病因子過度刺激噬骨細胞活化造成骨質的侵蝕與流失。我們實驗室主要在探討骨細胞間的訊息傳遞,並透過不同的動物模型來研究類風濕性關節炎(rheumatoid arthritis)與骨質疏鬆症(osteoporosis)。另外,隨著人口老化,忍受退化性骨關節炎(osteoarthritis)困擾的病人也日益增加。我們會針對軟骨組織(cartilage)中的軟骨細胞(chondrocyte)進行研究。由於軟骨組織
沒有血管提供養分,因此,軟骨細胞的新陳代謝也非常緩慢。當軟骨組織成熟後,成熟的軟骨細胞就會停止分裂並將自己包覆在其釋放的膠原蛋白中,構成了堅韌的細胞外間質。一旦軟骨細胞受到老化或是創傷所誘發的因子就會開始進行不可逆的細胞凋亡,軟骨組織漸漸地磨損、腐蝕到軟骨下方的骨頭時,就會有疼痛、腫脹等現象產生。因此,我們研究會著重於軟骨細胞代謝相關的基因,並將研究結果運用在軟骨組織的再生醫學開發上。
癌細胞骨轉移/Tumor-Bone metastasis
癌細胞骨轉移,即自原發性腫瘤(常見如前列腺癌,乳腺癌和肺癌)的癌細胞擴散到骨骼。這將使癌症的治療更加困難,亦增加了患者的死亡率和癌復發率。一直以來,骨髓組織已被認知是個富含生長因子的獨特環境,非常適合轉移性瘤細胞建群。在成骨期間,成骨細胞鋪設多種生長因子,將其併入骨基質中(bone matrix)。因此,瘤細胞會釋放諸如TNF和RANKL等因子,直接刺激破骨細胞的活化,使骨基質分解以補充腫瘤生長因子。然而,乳腺癌和前列腺癌患者骨轉移的高發生率與潛在性分子相互作用的關連性,一直未被深入研究。我們將積極地去探討這類癌細胞偏好骨轉移的誘因,是否與骨細胞表面的特定抗原有關?而這樣轉移的行為是否也和特定免疫細胞的歸巢行為有共通性? 在未來的計劃中,我希望結合癌症生物學和骨細胞生物學的研究經驗,來開發針對腫瘤細胞介導的骨基質重塑的免疫治療,以降低癌細胞骨轉移的發生。
產學合作/藥物開發
Preclinical animal models
免疫風濕關節炎模型
第二型膠原蛋白誘發小鼠關節炎,腳掌組織染色
骨質疏鬆症模型
藥物治療小鼠骨質疏鬆症,脛骨CT scan
肺纖維化模型
藥物誘發小鼠肺纖維化,肺組織染色
CADETS
Here's our first troop of adventurers!
尤達大師
榮譽博士
秀羚
碩士級研究助理 (2023/09~)
容安
碩士級研究助理 (2023/09~)
詠勳
碩士班行政助理 (2021/10~)
威利
博士班學生(2024/02)
沁緹
碩士班學生 (2023/02~)
宜桓
碩士班學生(2023/09~)
旻蓁
碩士班學生(2024/09~)
巧芸
北一女專題生 (2020/4~)
(專題競賽特優)
感謝你的貢獻
Apprentice:
- 謝佳燁 (106, work at GSK)
- 林佳宣 (106)
- 徐小涵 (107, work at 中化製藥)
- 林潔明 (108, work at 台灣醣聯 )
- 李佳臻 (109-110 summer)
- 林軒羽 (109)
- 歐映廷 (110)
- 張秀羚(111)
- 林容安(111)
- 鍾巧芸(109-111北一女科學班專題)
- 劉濬維(110-111大專生專題計畫)
感謝你的貢獻
Research Technician
- 林佳宣2018-19
- 洪雅雯2019-20
- 黃詣晴2019-20
- 鄭濡萱2020-22
- 林軒羽2021-22
- 林佩珊2022-23
- 黃靖惠2023-24postDr(東華大學助理教授)
實驗室特色/Lab style
本實驗室歡迎
- 具研究熱忱
- 樂當神隊友
- 敢於孤獨的勇氣
In this lab,
You don’t work hard, but work smart….
Schedule
工作時間的自由度與你的實驗成果正相關
文章討論/進度報告: 一個月一次
實驗討論:隨時。
畢業條件:
碩士:2年
博士:本所最低要求為1篇績優論文 (排名<20%)
Achievement
Award
DOKTORANDEN-STIPENDIEN: 2011-2014
Bayerischen Forschungsstiftung 巴伐利亞博士獎學金
Publications
2021-now
- Lin NY*, Lee JJ, Chen ST, Lin JA, Lin CH, Lin HY, Su YH, Chen CC, Lin MC, Kuo CY*, Huang MC*. Truncation of GalNAc-type O-glycans Suppresses CD44-mediated Osteoclastogenesis and Bone Metastasis in Breast Cancer. Mol Cancer Res. 2023 Jul. * Corresponding Author
- Chen TY*, Lin NY*, Wen CH, Lin CA, Venkatesan P, Wijerathna P, Lin CY, Lai PS. Development of triamcinolone acetonide-hyaluronic acid conjugates with selective targeting and less osteoporosis effect for rheumatoid arthritis treatments. Int J Biol Macromol. 2023 Mar
- Liao YY, Chuang YT, Lin HY, Lin NY, Hsu TW, Hsieh SC, Chen ST, Hung JS, Yang HJ, Liang JT, Huang MC, Huang J. GALNT2 promotes invasiveness of colorectal cancer cells partly through AXL. Mol Oncol. 2023 Jan
- Lin NY, Chen ST, Chang HL, Lu MY, Yang YL, Chou SW, Lin DT, Lin KH, Jou ST, Hsu WM, Huang MC, Chang HH. C1GALT1 expression predicts a favorable prognosis and suppresses malignant phenotypes via TrkA signaling in neuroblastoma. Oncogenesis. 2022 Feb
- Li YN, Chen CW, Trinh-Minh T, Zhu H, Matei AE, Györfi AH, Kuwert F, Hubel P, Ding X, Manh CT, Xu X, Liebel C, Fedorchenko V, Liang R, Huang K, Pfannstiel J, Huang MC, Lin NY, Ramming A, Schett G, Distler JHW.Dynamic changes in O-GlcNAcylation regulate osteoclast differentiation and bone loss via nucleoporin 153. Bone Res. 2022 Jul.
- Zehender A*, Li YN*, Lin NY*, Stefanica A, Nüchel J, Chen CW, Hsu HH, Zhu H, Ding X, Huang J, Shen L, Györfi AH, Soare A, Rauber S, Bergmann C, Ramming A, Plomann M, Eckes B, Schett G, Distler JHW. TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy. Nat Commun. 2021 Jul.
2016-2020
- Rauber S, Luber M, Weber S, Maul L, Soare A, Wohlfahrt T, Lin NY, Dietel K, Bozec A, Herrmann M, Kaplan MH, Weigmann B, Zaiss MM, Fearon U, Veale DJ, Cañete JD, Distler O, Rivellese F, Pitzalis C, Neurath MF, McKenzie ANJ, Wirtz S, Schett G, Distler JHW, Ramming A. Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells Nat Med. 2017 Aug;23(8):938-944. doi: 10.1038/nm.4373. Epub 2017 Jul 17.
- Lin NY, Alfiya Distler, Christian Beyer, Ariella Philipi-Schöbinger, Clara Dees, Michael Stock, Michal Tomcik, Andreas Niemeier, Francesco Dell'Accio, Kolja Gelse, Mark P. Mattson, Georg Schett, Jörg H.W. Distler. Inhibition of Notch1 promotes hedgehog signaling in a HES1-dependent manner in chondrocytes and exacerbates experimental osteoarthritis. Ann Rheum Dis. 2016 Nov.
- Lin NY, Chen CW, Kagwiria R, Liang R, Beyer C, Distler A, Luther J, Engelke K, Schett G, Distler JH. Inactivation of autophagy ameliorates glucocorticoid-induced and ovariectomy-induced bone loss. Ann Rheum Dis. 2016 Jun 25.
2011-2015
- Distler A, Lang V, Del Vecchio T, Huang J, Zhang Y, Beyer C, Lin NY, Palumbo-Zerr K, Distler O, Schett G, Distler JH. Combined inhibition of morphogen pathways demonstrates additive antifibrotic effects and improved tolerability. Ann Rheum Dis. 2014 Jun.
- Dees C, Schlottmann I, Funke R, Distler A, Palumbo-Zerr K, Zerr P, Lin NY, Beyer C, Distler O, Schett G, Distler JH. The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis. Ann Rheum Dis. 2014 Jun.
- Distler A, Ziemer C, Beyer C, Lin NY, Chen CW, Palumbo-Zerr K, Dees C, Weidemann A, Distler O, Schett G, Distler JH. Inactivation of evenness interrupted (EVI) reduces experimental fibrosis by combined inhibition of canonical and non-canonical Wnt signalling. sAnn Rheum Dis. 2014 Mar.
- Beyer C, Zampetaki A, Lin NY, Kleyer A, Perricone C, Iagnocco A, Distler A, Langley SR, Gelse K, Sesselmann S, Lorenzini R, Niemeier A, Swoboda B, Distler JH, Santer P, Egger G, Willeit J, Mayr M, Schett G, Kiechl S. Signature of circulating microRNAs in osteoarthritis. Ann Rheum Dis. 2014 Feb.
- Zhang Y, Dees C, Beyer C, Lin NY, Distler A, Zerr P, Palumbo K, Susok L, Kreuter A, Distler O, Schett G, Distler JH. Inhibition of casein kinase II reduces TGFβ induced fibroblast activation and ameliorates experimental fibrosis. Ann Rheum Dis. 2014 Jan.
- Distler A, Deloch L, Huang J, Dees C, Lin NY, Palumbo-Zerr K, Beyer C, Weidemann A,Distler O, Schett G, Distler JH. Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling. Ann Rheum Dis. 2013 Sep.
- Beyer C, Reichert H, Akan H, Mallano T, Schramm A, Dees C, Palumbo-Zerr K, Lin NY,Distler A, Gelse K, Varga J, Distler O, Schett G, Distler JH. Blockade of canonical Wnt signalling ameliorates experimental dermal fibrosis. Ann Rheum Dis. 2013 Jul. IF=10.38
- Huang J, Che MI, Lin NY, Hung JS, Huang YT, Lin WC, Huang HC, Lee PH, Liang JT, Huang MC. The molecular chaperone Cosmc enhances malignant behaviors of colon cancer cells via activation of Akt and ERK. Mol Carcinog. 2014 Feb
- Lin NY, Beyer C, Giessl A, Kireva T, Scholtysek C, Uderhardt S, Munoz LE, Dees C, Distler A, Wirtz S, Krönke G, Spencer B, Distler O, Schett G, Distler JH. Autophagy regulates TNFα-mediated joint destruction in experimental arthritis. Ann Rheum Dis. 2013 May.
- Lin NY, Stefanica A, Distler JH. Autophagy: a key pathway of TNF-induced inflammatory bone loss. Autophagy. 2013 Aug.
- Shyu MK, Chen CW, Lin NY, Liao WC, Chen CH, Lin CJ, Huang HC, Lee JJ, Huang MJ, Tseng GF, Shih JC, Lee CN, Hsieh FJ, Huang MC. MUC1 expression is elevated in severe preeclamptic placentas and suppresses trophoblast cell invasion via β1-integrin signaling. J Clin Endocrinol Metab. 2011 Dec.
~2010
- Huang J, Liang JT, Huang HC, Shen TL, Chen HY, Lin NY, Che MI, Lin WC, Huang MC. Beta1,4-N-acetylgalactosaminyltransferase III enhances malignant phenotypes of coloncancer cells. Mol Cancer Res. 2007 Jun.
- Huang MC, Chen HY, Huang HC, Huang J, Liang JT, Shen TL, Lin NY, Ho CC, Cho IM, Hsu SM. C2GnT-M is downregulated in colorectal cancer and its re-expression causes growth inhibition of colon cancer cells. Oncogene. 2006 Jun.
Industry cooperation
- 台灣醣聯(2022)
Lectures
大體解剖學: Pterygopalatine Fossa, Infratemporal Fossa
組織學: Ear Eye
細胞生物學導論:Cell membrane
C course: Immune system and respiratory system
Contact us
10051 台北市中正區仁愛路一段一號六樓 台大醫學院 解剖學暨細胞生物學研究所
6F, No.1, Sec. 1, Ren-ai Road,Taipei,10051,Taiwan, Anatomy NTUopen hour
Tuesday-Thursday 14:00-16:00886-2-23123456 ext. 88179
Last updated: 2023/09/15